CovidSeniorV1, Main, Exploration, bibRecord, 000333

Prevalence and Outcomes of D-Dimer Elevation in Hospitalized Patients With COVID-19.

Identifieur interne : 000333 ( Main/Exploration ); précédent : 000332; suivant : 000334

Prevalence and Outcomes of D-Dimer Elevation in Hospitalized Patients With COVID-19.

Auteurs : Jeffrey S. Berger [États-Unis] ; Dennis Kunichoff ; Samrachana Adhikari ; Tania Ahuja [États-Unis] ; Nancy Amoroso ; Yindalon Aphinyanaphongs ; Meng Cao ; Ronald Goldenberg ; Alexander Hindenburg ; James Horowitz ; Sam Parnia ; Christopher Petrilli ; Harmony Reynolds ; Emma Simon ; James Slater ; Shadi Yaghi ; Eugene Yuriditsky ; Judith Hochman ; Leora I. Horwitz

Source :

Arteriosclerosis, thrombosis, and vascular biology [ 1524-4636 ] ; 2020.

RBID : pubmed:32840379

Descripteurs français

English descriptors

KwdEn :
- Adult (MeSH), Aged (MeSH), Biomarkers (blood), Cause of Death (MeSH), Cohort Studies (MeSH), Coronavirus Infections (blood), Coronavirus Infections (mortality), Coronavirus Infections (physiopathology), Critical Illness (epidemiology), Databases, Factual (MeSH), Disease Progression (MeSH), Female (MeSH), Fibrin Fibrinogen Degradation Products (metabolism), Hospital Mortality (trends), Hospitals, Urban (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), New York City (epidemiology), Pandemics (MeSH), Pneumonia, Viral (blood), Pneumonia, Viral (mortality), Pneumonia, Viral (physiopathology), Prevalence (MeSH), Retrospective Studies (MeSH), Risk Assessment (MeSH), Severe Acute Respiratory Syndrome (blood), Severe Acute Respiratory Syndrome (mortality), Severe Acute Respiratory Syndrome (physiopathology), Severity of Illness Index (MeSH).
MESH :
- chemical , blood : Biomarkers.
- geographic , epidemiology : New York City.
- blood : Coronavirus Infections, Pneumonia, Viral, Severe Acute Respiratory Syndrome.
- epidemiology : Critical Illness.
- chemical , metabolism : Fibrin Fibrinogen Degradation Products.
- mortality : Coronavirus Infections, Pneumonia, Viral, Severe Acute Respiratory Syndrome.
- physiopathology : Coronavirus Infections, Pneumonia, Viral, Severe Acute Respiratory Syndrome.
- trends : Hospital Mortality.
- Adult, Aged, Cause of Death, Cohort Studies, Databases, Factual, Disease Progression, Female, Hospitals, Urban, Humans, Male, Middle Aged, Pandemics, Prevalence, Retrospective Studies, Risk Assessment, Severity of Illness Index.

Abstract

OBJECTIVE

To determine the prevalence of D-dimer elevation in coronavirus disease 2019 (COVID-19) hospitalization, trajectory of D-dimer levels during hospitalization, and its association with clinical outcomes. Approach and Results: Consecutive adults admitted to a large New York City hospital system with a positive polymerase chain reaction test for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) between March 1, 2020 and April 8, 2020 were identified. Elevated D-dimer was defined by the laboratory-specific upper limit of normal (>230 ng/mL). Outcomes included critical illness (intensive care, mechanical ventilation, discharge to hospice, or death), thrombotic events, acute kidney injury, and death during admission. Among 2377 adults hospitalized with COVID-19 and ≥1 D-dimer measurement, 1823 (76%) had elevated D-dimer at presentation. Patients with elevated presenting baseline D-dimer were more likely than those with normal D-dimer to have critical illness (43.9% versus 18.5%; adjusted odds ratio, 2.4 [95% CI, 1.9-3.1];

CONCLUSIONS

Abnormal D-dimer was frequently observed at admission with COVID-19 and was associated with higher incidence of critical illness, thrombotic events, acute kidney injury, and death. The optimal management of patients with elevated D-dimer in COVID-19 requires further study.

DOI: 10.1161/ATVBAHA.120.314872
PubMed: 32840379
PubMed Central: PMC7505147

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000502
to stream Main, to step Curation: 000502

Le document en format XML

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<wicri:noCountry code="subField">J</wicri:noCountry>
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<author><name sortKey="Reynolds, Harmony" sort="Reynolds, Harmony" uniqKey="Reynolds H" first="Harmony" last="Reynolds">Harmony Reynolds</name>
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<wicri:noCountry code="subField">J</wicri:noCountry>
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<wicri:noCountry code="subField">J</wicri:noCountry>
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<wicri:noCountry code="subField">J</wicri:noCountry>
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<wicri:noCountry code="subField">J</wicri:noCountry>
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<author><name sortKey="Horwitz, Leora I" sort="Horwitz, Leora I" uniqKey="Horwitz L" first="Leora I" last="Horwitz">Leora I. Horwitz</name>
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<wicri:noCountry code="subField">L.I.H.).</wicri:noCountry>
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<affiliation><nlm:affiliation>Division of Healthcare Delivery Science, Department of Population Health, New York (E.S., L.I.H.).</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Prevalence and Outcomes of D-Dimer Elevation in Hospitalized Patients With COVID-19.</title>
<author><name sortKey="Berger, Jeffrey S" sort="Berger, Jeffrey S" uniqKey="Berger J" first="Jeffrey S" last="Berger">Jeffrey S. Berger</name>
<affiliation><nlm:affiliation>Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York (J.S.B., J. Horowitz, C.P., H.R., J.S., E.Y., J. Hochman).</nlm:affiliation>
<wicri:noCountry code="subField">J</wicri:noCountry>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Center for Prevention of Cardiovascular Disease (J.S.B.), NYU Langone Health, New York.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
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<author><name sortKey="Kunichoff, Dennis" sort="Kunichoff, Dennis" uniqKey="Kunichoff D" first="Dennis" last="Kunichoff">Dennis Kunichoff</name>
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<wicri:noCountry code="subField">S.A.).</wicri:noCountry>
</affiliation>
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<author><name sortKey="Adhikari, Samrachana" sort="Adhikari, Samrachana" uniqKey="Adhikari S" first="Samrachana" last="Adhikari">Samrachana Adhikari</name>
<affiliation><nlm:affiliation>Division of Biostatistics, Department of Population Health, New York (D.K., S.A.).</nlm:affiliation>
<wicri:noCountry code="subField">S.A.).</wicri:noCountry>
</affiliation>
</author>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Pharmacy (T.A.), NYU Langone Health</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Amoroso, Nancy" sort="Amoroso, Nancy" uniqKey="Amoroso N" first="Nancy" last="Amoroso">Nancy Amoroso</name>
<affiliation><nlm:affiliation>Division of Pulmonary Critical Care, Department of Medicine, New York (N.A., S.P.).</nlm:affiliation>
<wicri:noCountry code="subField">S.P.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Aphinyanaphongs, Yindalon" sort="Aphinyanaphongs, Yindalon" uniqKey="Aphinyanaphongs Y" first="Yindalon" last="Aphinyanaphongs">Yindalon Aphinyanaphongs</name>
<affiliation><nlm:affiliation>Center for Healthcare Innovation and Delivery Science, New York (Y.A.).</nlm:affiliation>
<wicri:noCountry code="subField">New York (Y.A.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Cao, Meng" sort="Cao, Meng" uniqKey="Cao M" first="Meng" last="Cao">Meng Cao</name>
<affiliation><nlm:affiliation>Division of General Internal Medicine and Clinical Innovation, Department of Medicine, New York (M.C., C.P., L.I.H.).</nlm:affiliation>
<wicri:noCountry code="subField">L.I.H.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Goldenberg, Ronald" sort="Goldenberg, Ronald" uniqKey="Goldenberg R" first="Ronald" last="Goldenberg">Ronald Goldenberg</name>
</author>
<author><name sortKey="Hindenburg, Alexander" sort="Hindenburg, Alexander" uniqKey="Hindenburg A" first="Alexander" last="Hindenburg">Alexander Hindenburg</name>
<affiliation><nlm:affiliation>Division of Hematology and Oncology, NYU Winthrop Hospital, Mineola, NY (A.H.).</nlm:affiliation>
<wicri:noCountry code="subField">NY (A.H.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Horowitz, James" sort="Horowitz, James" uniqKey="Horowitz J" first="James" last="Horowitz">James Horowitz</name>
<affiliation><nlm:affiliation>Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York (J.S.B., J. Horowitz, C.P., H.R., J.S., E.Y., J. Hochman).</nlm:affiliation>
<wicri:noCountry code="subField">J</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Parnia, Sam" sort="Parnia, Sam" uniqKey="Parnia S" first="Sam" last="Parnia">Sam Parnia</name>
<affiliation><nlm:affiliation>Division of Pulmonary Critical Care, Department of Medicine, New York (N.A., S.P.).</nlm:affiliation>
<wicri:noCountry code="subField">S.P.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Petrilli, Christopher" sort="Petrilli, Christopher" uniqKey="Petrilli C" first="Christopher" last="Petrilli">Christopher Petrilli</name>
<affiliation><nlm:affiliation>Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York (J.S.B., J. Horowitz, C.P., H.R., J.S., E.Y., J. Hochman).</nlm:affiliation>
<wicri:noCountry code="subField">J</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Division of General Internal Medicine and Clinical Innovation, Department of Medicine, New York (M.C., C.P., L.I.H.).</nlm:affiliation>
<wicri:noCountry code="subField">L.I.H.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Reynolds, Harmony" sort="Reynolds, Harmony" uniqKey="Reynolds H" first="Harmony" last="Reynolds">Harmony Reynolds</name>
<affiliation><nlm:affiliation>Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York (J.S.B., J. Horowitz, C.P., H.R., J.S., E.Y., J. Hochman).</nlm:affiliation>
<wicri:noCountry code="subField">J</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Simon, Emma" sort="Simon, Emma" uniqKey="Simon E" first="Emma" last="Simon">Emma Simon</name>
<affiliation><nlm:affiliation>Division of Healthcare Delivery Science, Department of Population Health, New York (E.S., L.I.H.).</nlm:affiliation>
<wicri:noCountry code="subField">L.I.H.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Slater, James" sort="Slater, James" uniqKey="Slater J" first="James" last="Slater">James Slater</name>
<affiliation><nlm:affiliation>Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York (J.S.B., J. Horowitz, C.P., H.R., J.S., E.Y., J. Hochman).</nlm:affiliation>
<wicri:noCountry code="subField">J</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Yaghi, Shadi" sort="Yaghi, Shadi" uniqKey="Yaghi S" first="Shadi" last="Yaghi">Shadi Yaghi</name>
<affiliation><nlm:affiliation>Department of Neurology, NYU Grossman School of Medicine, Brooklyn, NY(S.Y.).</nlm:affiliation>
<wicri:noCountry code="subField">NY(S.Y.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Yuriditsky, Eugene" sort="Yuriditsky, Eugene" uniqKey="Yuriditsky E" first="Eugene" last="Yuriditsky">Eugene Yuriditsky</name>
<affiliation><nlm:affiliation>Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York (J.S.B., J. Horowitz, C.P., H.R., J.S., E.Y., J. Hochman).</nlm:affiliation>
<wicri:noCountry code="subField">J</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hochman, Judith" sort="Hochman, Judith" uniqKey="Hochman J" first="Judith" last="Hochman">Judith Hochman</name>
<affiliation><nlm:affiliation>Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York (J.S.B., J. Horowitz, C.P., H.R., J.S., E.Y., J. Hochman).</nlm:affiliation>
<wicri:noCountry code="subField">J</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Horwitz, Leora I" sort="Horwitz, Leora I" uniqKey="Horwitz L" first="Leora I" last="Horwitz">Leora I. Horwitz</name>
<affiliation><nlm:affiliation>Division of General Internal Medicine and Clinical Innovation, Department of Medicine, New York (M.C., C.P., L.I.H.).</nlm:affiliation>
<wicri:noCountry code="subField">L.I.H.).</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Division of Healthcare Delivery Science, Department of Population Health, New York (E.S., L.I.H.).</nlm:affiliation>
<wicri:noCountry code="subField">L.I.H.).</wicri:noCountry>
</affiliation>
</author>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Biomarkers (blood)</term>
<term>Cause of Death (MeSH)</term>
<term>Cohort Studies (MeSH)</term>
<term>Coronavirus Infections (blood)</term>
<term>Coronavirus Infections (mortality)</term>
<term>Coronavirus Infections (physiopathology)</term>
<term>Critical Illness (epidemiology)</term>
<term>Databases, Factual (MeSH)</term>
<term>Disease Progression (MeSH)</term>
<term>Female (MeSH)</term>
<term>Fibrin Fibrinogen Degradation Products (metabolism)</term>
<term>Hospital Mortality (trends)</term>
<term>Hospitals, Urban (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>New York City (epidemiology)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (blood)</term>
<term>Pneumonia, Viral (mortality)</term>
<term>Pneumonia, Viral (physiopathology)</term>
<term>Prevalence (MeSH)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Risk Assessment (MeSH)</term>
<term>Severe Acute Respiratory Syndrome (blood)</term>
<term>Severe Acute Respiratory Syndrome (mortality)</term>
<term>Severe Acute Respiratory Syndrome (physiopathology)</term>
<term>Severity of Illness Index (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Appréciation des risques (MeSH)</term>
<term>Bases de données factuelles (MeSH)</term>
<term>Cause de décès (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Hôpitaux urbains (MeSH)</term>
<term>Indice de gravité de la maladie (MeSH)</term>
<term>Infections à coronavirus (mortalité)</term>
<term>Infections à coronavirus (physiopathologie)</term>
<term>Infections à coronavirus (sang)</term>
<term>Maladie grave (épidémiologie)</term>
<term>Marqueurs biologiques (sang)</term>
<term>Mortalité hospitalière (tendances)</term>
<term>Mâle (MeSH)</term>
<term>New York (ville) (épidémiologie)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (mortalité)</term>
<term>Pneumopathie virale (physiopathologie)</term>
<term>Pneumopathie virale (sang)</term>
<term>Produits de dégradation de la fibrine et du fibrinogène (métabolisme)</term>
<term>Prévalence (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Syndrome respiratoire aigu sévère (mortalité)</term>
<term>Syndrome respiratoire aigu sévère (physiopathologie)</term>
<term>Syndrome respiratoire aigu sévère (sang)</term>
<term>Études de cohortes (MeSH)</term>
<term>Études rétrospectives (MeSH)</term>
<term>Évolution de la maladie (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>New York City</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Critical Illness</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fibrin Fibrinogen Degradation Products</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Produits de dégradation de la fibrine et du fibrinogène</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Marqueurs biologiques</term>
<term>Pneumopathie virale</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="tendances" xml:lang="fr"><term>Mortalité hospitalière</term>
</keywords>
<keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Hospital Mortality</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Maladie grave</term>
<term>New York (ville)</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Cause of Death</term>
<term>Cohort Studies</term>
<term>Databases, Factual</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Hospitals, Urban</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Prevalence</term>
<term>Retrospective Studies</term>
<term>Risk Assessment</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Appréciation des risques</term>
<term>Bases de données factuelles</term>
<term>Cause de décès</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hôpitaux urbains</term>
<term>Indice de gravité de la maladie</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Prévalence</term>
<term>Sujet âgé</term>
<term>Études de cohortes</term>
<term>Études rétrospectives</term>
<term>Évolution de la maladie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>To determine the prevalence of D-dimer elevation in coronavirus disease 2019 (COVID-19) hospitalization, trajectory of D-dimer levels during hospitalization, and its association with clinical outcomes. Approach and Results: Consecutive adults admitted to a large New York City hospital system with a positive polymerase chain reaction test for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) between March 1, 2020 and April 8, 2020 were identified. Elevated D-dimer was defined by the laboratory-specific upper limit of normal (>230 ng/mL). Outcomes included critical illness (intensive care, mechanical ventilation, discharge to hospice, or death), thrombotic events, acute kidney injury, and death during admission. Among 2377 adults hospitalized with COVID-19 and ≥1 D-dimer measurement, 1823 (76%) had elevated D-dimer at presentation. Patients with elevated presenting baseline D-dimer were more likely than those with normal D-dimer to have critical illness (43.9% versus 18.5%; adjusted odds ratio, 2.4 [95% CI, 1.9-3.1]; </p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Abnormal D-dimer was frequently observed at admission with COVID-19 and was associated with higher incidence of critical illness, thrombotic events, acute kidney injury, and death. The optimal management of patients with elevated D-dimer in COVID-19 requires further study.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32840379</PMID>
<DateCompleted><Year>2020</Year>
<Month>10</Month>
<Day>05</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>10</Month>
<Day>05</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1524-4636</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>40</Volume>
<Issue>10</Issue>
<PubDate><Year>2020</Year>
<Month>10</Month>
</PubDate>
</JournalIssue>
<Title>Arteriosclerosis, thrombosis, and vascular biology</Title>
<ISOAbbreviation>Arterioscler Thromb Vasc Biol</ISOAbbreviation>
</Journal>
<ArticleTitle>Prevalence and Outcomes of D-Dimer Elevation in Hospitalized Patients With COVID-19.</ArticleTitle>
<Pagination><MedlinePgn>2539-2547</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1161/ATVBAHA.120.314872</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE">To determine the prevalence of D-dimer elevation in coronavirus disease 2019 (COVID-19) hospitalization, trajectory of D-dimer levels during hospitalization, and its association with clinical outcomes. Approach and Results: Consecutive adults admitted to a large New York City hospital system with a positive polymerase chain reaction test for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) between March 1, 2020 and April 8, 2020 were identified. Elevated D-dimer was defined by the laboratory-specific upper limit of normal (>230 ng/mL). Outcomes included critical illness (intensive care, mechanical ventilation, discharge to hospice, or death), thrombotic events, acute kidney injury, and death during admission. Among 2377 adults hospitalized with COVID-19 and ≥1 D-dimer measurement, 1823 (76%) had elevated D-dimer at presentation. Patients with elevated presenting baseline D-dimer were more likely than those with normal D-dimer to have critical illness (43.9% versus 18.5%; adjusted odds ratio, 2.4 [95% CI, 1.9-3.1]; <i>P</i>
<0.001), any thrombotic event (19.4% versus 10.2%; adjusted odds ratio, 1.9 [95% CI, 1.4-2.6]; <i>P</i>
<0.001), acute kidney injury (42.4% versus 19.0%; adjusted odds ratio, 2.4 [95% CI, 1.9-3.1]; <i>P</i>
<0.001), and death (29.9% versus 10.8%; adjusted odds ratio, 2.1 [95% CI, 1.6-2.9]; <i>P</i>
<0.001). Rates of adverse events increased with the magnitude of D-dimer elevation; individuals with presenting D-dimer >2000 ng/mL had the highest risk of critical illness (66%), thrombotic event (37.8%), acute kidney injury (58.3%), and death (47%).</AbstractText>
<AbstractText Label="CONCLUSIONS">Abnormal D-dimer was frequently observed at admission with COVID-19 and was associated with higher incidence of critical illness, thrombotic events, acute kidney injury, and death. The optimal management of patients with elevated D-dimer in COVID-19 requires further study.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Berger</LastName>
<ForeName>Jeffrey S</ForeName>
<Initials>JS</Initials>
<AffiliationInfo><Affiliation>Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York (J.S.B., J. Horowitz, C.P., H.R., J.S., E.Y., J. Hochman).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Prevention of Cardiovascular Disease (J.S.B.), NYU Langone Health, New York.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kunichoff</LastName>
<ForeName>Dennis</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Division of Biostatistics, Department of Population Health, New York (D.K., S.A.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Adhikari</LastName>
<ForeName>Samrachana</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Division of Biostatistics, Department of Population Health, New York (D.K., S.A.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ahuja</LastName>
<ForeName>Tania</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacy (T.A.), NYU Langone Health, New York.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Amoroso</LastName>
<ForeName>Nancy</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Division of Pulmonary Critical Care, Department of Medicine, New York (N.A., S.P.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Aphinyanaphongs</LastName>
<ForeName>Yindalon</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Center for Healthcare Innovation and Delivery Science, New York (Y.A.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cao</LastName>
<ForeName>Meng</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Division of General Internal Medicine and Clinical Innovation, Department of Medicine, New York (M.C., C.P., L.I.H.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Goldenberg</LastName>
<ForeName>Ronald</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hindenburg</LastName>
<ForeName>Alexander</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Division of Hematology and Oncology, NYU Winthrop Hospital, Mineola, NY (A.H.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Horowitz</LastName>
<ForeName>James</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York (J.S.B., J. Horowitz, C.P., H.R., J.S., E.Y., J. Hochman).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Parnia</LastName>
<ForeName>Sam</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Division of Pulmonary Critical Care, Department of Medicine, New York (N.A., S.P.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Petrilli</LastName>
<ForeName>Christopher</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York (J.S.B., J. Horowitz, C.P., H.R., J.S., E.Y., J. Hochman).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of General Internal Medicine and Clinical Innovation, Department of Medicine, New York (M.C., C.P., L.I.H.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Reynolds</LastName>
<ForeName>Harmony</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York (J.S.B., J. Horowitz, C.P., H.R., J.S., E.Y., J. Hochman).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Simon</LastName>
<ForeName>Emma</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Division of Healthcare Delivery Science, Department of Population Health, New York (E.S., L.I.H.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Slater</LastName>
<ForeName>James</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York (J.S.B., J. Horowitz, C.P., H.R., J.S., E.Y., J. Hochman).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yaghi</LastName>
<ForeName>Shadi</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, NYU Grossman School of Medicine, Brooklyn, NY(S.Y.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yuriditsky</LastName>
<ForeName>Eugene</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York (J.S.B., J. Horowitz, C.P., H.R., J.S., E.Y., J. Hochman).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hochman</LastName>
<ForeName>Judith</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York (J.S.B., J. Horowitz, C.P., H.R., J.S., E.Y., J. Hochman).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Horwitz</LastName>
<ForeName>Leora I</ForeName>
<Initials>LI</Initials>
<AffiliationInfo><Affiliation>Division of General Internal Medicine and Clinical Innovation, Department of Medicine, New York (M.C., C.P., L.I.H.).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Healthcare Delivery Science, Department of Population Health, New York (E.S., L.I.H.).</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 HL139909</GrantID>
<Acronym>HL</Acronym>
<Agency>NHLBI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R35 HL144993</GrantID>
<Acronym>HL</Acronym>
<Agency>NHLBI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>UL1 TR001445</GrantID>
<Acronym>TR</Acronym>
<Agency>NCATS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>08</Month>
<Day>25</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Arterioscler Thromb Vasc Biol</MedlineTA>
<NlmUniqueID>9505803</NlmUniqueID>
<ISSNLinking>1079-5642</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D005338">Fibrin Fibrinogen Degradation Products</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C036309">fibrin fragment D</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002423" MajorTopicYN="N">Cause of Death</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016638" MajorTopicYN="N">Critical Illness</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016208" MajorTopicYN="N">Databases, Factual</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018450" MajorTopicYN="Y">Disease Progression</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005338" MajorTopicYN="N">Fibrin Fibrinogen Degradation Products</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017052" MajorTopicYN="N">Hospital Mortality</DescriptorName>
<QualifierName UI="Q000639" MajorTopicYN="Y">trends</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006786" MajorTopicYN="N">Hospitals, Urban</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009519" MajorTopicYN="N" Type="Geographic">New York City</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">acute kidney injury</Keyword>
<Keyword MajorTopicYN="Y">critical illness</Keyword>
<Keyword MajorTopicYN="Y">epidemiology</Keyword>
<Keyword MajorTopicYN="Y">mortality</Keyword>
<Keyword MajorTopicYN="Y">thrombosis</Keyword>
</KeywordList>
</MedlineCitation>
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<Month>8</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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Prevalence and Outcomes of D-Dimer Elevation in Hospitalized Patients With COVID-19.

Prevalence and Outcomes of D-Dimer Elevation in Hospitalized Patients With COVID-19.

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